Formulation and Optimization of Ketoprofen Loaded Solid Lipid Nanoparticles Using Central Composite Design
نویسندگان
چکیده
منابع مشابه
Formulation and Physicochemical Characterization of Lycopene-Loaded Solid Lipid Nanoparticles.
PURPOSE Lycopene belongs to the carotenoids that shows good pharmacological properties including antioxidant, anti-inflammatory and anticancer. However, as a result of very low aqueous solubility, it has a limited systemic absorption, following oral administration. METHODS Here, we prepared a stable lycopene-loaded solid lipid nanoparticles using Precirol® ATO5, Compritol 888 ATO and myristic...
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INTRODUCTION Gemcitabine hydrochloride is an antimetabolite (pyrimidine analog) with poor oral bioavailability (9%) due to the first pass metabolism. GEM is a water soluble drug (log p = -1.4) with a short half-life of 42 to 94 minutes (short infusions) and 245 to 638 minutes (long infusions) respectively. Extensive first pass metabolism, low bioavailability, high dosing frequency and less half...
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Primaquine (PQ) is one of the most widely used antimalarial drugs and is the only available drug that combats the relapsing form of malaria. PQ use in higher doses is limited by severe tissue toxicity including hematological- and gastrointestinal-related side effects. Nanoformulation of drugs in an appropriate drug carrier system has been extensively studied and shown to have the potential to i...
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Solid Lipid Nanoparticles (SLNs) have emerged as an alternative colloidal carriers for sustained release of lipophilic drugs with poor absorption and water solubility. This manuscript describes the effect of process variables on the production of Solid Lipid Nanoparticles (SLNs) from beeswax and carnauba wax and ketoprofen release from these carriers. It was found that by increasing drug co...
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The number of new pharmaceutical compounds with poor aqueous solubility has grown steadily over the last two decades due to the progress in discovery technologies, e.g. high throughput and combinatorial screening tools, during lead development and optimization phase. Most of these compounds are mainly categorized as bio pharmaceutics classification system (BCS) class II for which their oral abs...
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ژورنال
عنوان ژورنال: Pharmaceutical and Biosciences Journal
سال: 2019
ISSN: 2582-0540
DOI: 10.20510/ukjpb/7/i5/1569656548